A key element of DDM is
the ability to utilize ChemoInformatics to generate novel chemical
entities that are biostructural equivalents. This allows for
the generation of novel compounds that have significant affinity
for a given biological target. This technique is extremely
valuable tool for:
Chemical lead development when limited biological structural
information is available.
Rescuing projects in which the current lead series has fatal
physical or physiochemical
properties, particularly when combined with our DDM ADMET
Expansion of intellectual property coverage.
Shown below are some examples of the
application of DDM to novel hit compound generation. In each case
a new novel ligand for the given biological target was identified
and verified within weeks of inception of the project.